If topical treatments don’t work or acne is severe, oral medications are often the next step.

“If you’ve tried several topical medications without success, or if your condition is severe, oral acne medications are usually the next step in the treatment process.” This usually includes oral antibiotics combined with prescription gels or creams.

For more severe cases, stronger solutions may be needed. “Depending on people with acne, treatment may include… taking stronger medications such as isotretinoin, or even minor surgery.” Birth control pills and hormone therapies are also common for managing hormonal acne.